Ibogaine influence on gene expression – Roman Paskulin

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Tabernanthe iboga with its alkaloid ibogaine is recognized in the West as a remedy against diverse addictions, while traditionally it is used as inductor of maturation. Its uniqueness lays in the multiple actions – it triggers psychedelic insights, facilitates metabolic adaptations and sets new spiritual habitus.
Our study was a quest for common denominator for these seemingly diverse effects through investigation of ibogaine’s influence on gene expression. The induction of energy metabolism related enzymes and facilitated shifts in homeostasis were found.
While various drugs of abuse interfere with energy metabolism findings suggest that facilitated detoxification, tolerance reversion and craving elimination are related to restoration of satisfactory bioenergetics.
Pharmacology of ibogaine and risk reduction measures should be evident to all who are about to enter such process; either self-healing, personal growth, spiritual insights, recreational use or just mere curiosity.


Roman Paškulin M.D., PhD. is a founder of OMI Institute for anthropological medicine and researcher in Laboratory for Neuroregeneration at University of Ljubljana. He studies impact of ibogaine on gene expression and metabolism. His special interests lie in lifestyle diseases, especially addiction and most of his work deals with »soul healing« herbs. He has conducted field researches on iboga, ayahuasca, and mandrake ethnopharmacology and is the author of a series of scientific publications that bridge molecular genetics with physiological, psychosocial and spiritual impact of entheogen use.


This video was shot at ICPR 2016, the Interdisciplinary Conference on Psychedelics Research, organized by The OPEN Foundation (Stichting OPEN in Dutch).

Stichting OPEN is an interdisciplinary organization which stimulates research into all aspects of the psychedelic experience. We spread honest information on both the potential and the risks of psychedelics – and hope to decrease the taboo that still surrounds the study of psychedelics. OPEN functions as a central node in an ever increasing network of national and international experts in the field of psychedelic research.