Ibogaine shares receptor effects with both Salvia divinorum (κ-opiate down-regulation of tolerance via beta-arrestin) and with ketamine (NMDA antagonism, curbing narcotic withdrawal and super-sensitization to stimulants). Additionally, ibogaine induces the nerve growth factor GDNF (Glia-Derived Neurotrophic Factor), re-sprouting chronically desensitised dopamine receptors and replacing the neural deficit experienced as craving. Moreover, the 10-fold GDNF spike engendered by ibogaine back-signals to cell nuclei to make more GDNF, setting ...
Mechanisms of Action of Ibogaine (PART 2)
Excerpt from the 2010 ICEERS Ibogaine Conference held at the Catalan Health Ministry.
Presentation by Kenneth R. Alper, M.D.
Visit www.iceers.org for more info.
source
Mechanisms of Action of Ibogaine (PART 1)
Excerpt from the 2010 ICEERS Ibogaine Conference held at the Catalan Health Ministry.
Presentation by Kenneth R. Alper, M.D.
Visit www.iceers.org for more info.
source