Clare S. Wilkins – A Novel Approach To Detoxification From Methadone With Ibogaine



The African psychoactive alkaloid Ibogaine, Schedule 1 in the USA, researched for substance use since the 1950’s, has demonstrated effectiveness in reversing tolerance & craving for opioids, stimulants & alcohol. Risks & fatalities are involved, due to the demographic, screening, inducing bradycardia, prolonging the QT interval & blocking the Potassium hERG channel, further complicated by opioid maintenance medications & psychiatric drugs. Almost all ibogaine centres, rapidly increasing in ...

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Dana Beal – Nerve Growth Factor GDNF Elucidates Ibogaine’s Persistence & Immune Modulatory Effects



Ibogaine shares receptor effects with both Salvia divinorum (κ-opiate down-regulation of tolerance via beta-arrestin) and with ketamine (NMDA antagonism, curbing narcotic withdrawal and super-sensitization to stimulants). Additionally, ibogaine induces the nerve growth factor GDNF (Glia-Derived Neurotrophic Factor), re-sprouting chronically desensitised dopamine receptors and replacing the neural deficit experienced as craving. Moreover, the 10-fold GDNF spike engendered by ibogaine back-signals to cell nuclei to make more GDNF, setting up ...

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