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Scientists used a compound found in a shrub native to Africa to reveal the three major shapes of the serotonin transporter, a protein in the brain linked to anxiety and depression.
Using cryo-electron microscopy, the scientists examined the protein binding to ibogaine, an alkaloid that alters brain function and occurs naturally in the shrub iboga. Using ibogaine, researchers reveal the structure of the serotonin transporter in its outward-open, closed and inward-open ...