Harm reduction strategies are designed to minimize the adverse effects of substance use rather than requiring abstinence. This concept often includes the use of natural substances as alternatives to more harmful or addictive drugs. Several substances are currently being explored for their therapeutic potential in reducing dependence on opioids, alcohol, and other addictive substances. The focus here is on three such natural substances: kratom, cannabidiol (CBD), and ibogaine. These compounds are being studied ...